Miserable while in quest of happiness?

(edited from Thomas Reade's, "The Thorns in the Parable")

Man has a natural thirst after happiness; but,
being blinded through the fall, and having all his
appetites vitiated, he is continually seeking that
from the world, which can only be found in God.

Fallen man, like Cain of old, is a fugitive.

He is ever flying from the presence of his Creator,
who is the source and center of true felicity.

He is daily committing two evils: "They have
forsaken Me, the spring of living water, and
have dug their own cisterns, broken cisterns
that cannot hold water." Jeremiah 2:13

Hence he is miserable while in quest of happiness.

He drinks of the intoxicating wine of carnal gratification;
revels for a time in sensual pleasure; and if he awakens
to sober recollection, feels a thousand stings, which too
often drive him to despair and death.